Conolidine alkaloid for chronic pain - An Overview
Most not too long ago, it has been discovered that conolidine and the above derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in similar regions as classical opioid receptors, it binds into a wide array of endogenous opioids. Unlike most opioid receptors, this receptor acts like a scavenger and will not activate a second messen